Young, M. A., Rees, S. D., Nicklisch, S. C. T., Stowell, M. H. B., Hamdoun, A., & Chang, G. (2025). Cryo-EM Structures of Apo and DDT-Bound P-Glycoprotein in Yellowfin Tuna. Environmental Science & Technology, 59(22), 11251–11260. https://doi.org/10.1021/acs.est.5c03398

Batzel, G., Wang, Y., Bock, A., Chen, E., Neal, S., Lopez‐Anido, R. N., Lee, Y., Tjeerdema, E., Ignatoff, E., Patil, T., Ramirez, G., Lesoway, M. P., Hamdoun, A., & Lyons, D. C. (2025). CRISPR/Cas9 Knockout of Shell Matrix Protein 1 in the Slipper‐Snail Crepidula atrasolea. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, jez.b.23293. https://doi.org/10.1002/jez.b.23293

Nesbit, K. T., Hargadon, A. C., Renaudin, G. D., Kraieski, N. D., Buckley, K. M., Darin, E., Lee, Y., Hamdoun, A., & Schrankel, C. S. (2024). Characterization of cellular and molecular immune components of the painted white sea urchin Lytechinus pictus in response to bacterial infection. Immunology & Cell Biology, imcb.12828. https://doi.org/10.1111/imcb.12828

Jackson, E. W., Romero, E., Kling, S., Lee, Y., Tjeerdema, E., & Hamdoun, A. (2024). Stable germline transgenesis using the Minos Tc1/ mariner element in the sea urchin Lytechinus pictus. Development, 151(20), dev202991. https://doi.org/10.1242/dev.202991

Barone, V., Tagua, A., Román, J. Á. A.-S., Hamdoun, A., Garrido-García, J., Lyons, D. C., & Escudero, L. M. (2024). Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium. Development, 151(20), dev202362. https://doi.org/10.1242/dev.202362

Vacquier, V. D., & Hamdoun, A. (2024). Cold storage and cryopreservation methods for spermatozoa of the sea urchins Lytechinus pictus and Strongylocentrotus purpuratus . Developmental Dynamics, dvdy.691. https://doi.org/10.1002/dvdy.691

Tate, H. M., Barone, V., Schrankel, C. S., Hamdoun, A., & Lyons, D. C. (2024). Localization and origins of juvenile skeletogenic cells in the sea urchin Lytechinus pictus. Developmental Biology, 514, 12–27. https://doi.org/10.1016/j.ydbio.2024.05.012

Tjeerdema, E., Lee, Y., Metry, R., & Hamdoun, A. (2023). Semi‐automated, high‐content imaging of drug transporter knockout sea urchin ( Lytechinus pictus ) embryos. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, jez.b.23231. https://doi.org/10.1002/jez.b.23231

Michel, M. E., Wen, C. C., Yee, S. W., Giacomini, K. M., Hamdoun, A., & Nicklisch, S. C. T. (2023). TICBase : Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters. Clinical Pharmacology & Therapeutics, cpt.3036. https://doi.org/10.1002/cpt.3036

Lee, Y., Tjeerdema, E., Kling, S., Chang, N., & Hamdoun, A. (2023). Solute carrier (SLC) expression reveals skeletogenic cell diversity. Developmental Biology, 503, 68–82. https://doi.org/10.1016/j.ydbio.2023.08.004

Vyas, H., Schrankel, C. S., Espinoza, J. A., Mitchell, K. L., Nesbit, K. T., Jackson, E., Chang, N., Lee, Y., Warner, J., Reitzel, A., Lyons, D. C., & Hamdoun, A. (2022). Generation of a homozygous mutant drug transporter (ABCB1) knockout line in the sea urchin Lytechinus pictus. Development, 149(11), 7. https://doi.org/10.1242/dev.200644

Nicklisch, S. C. T., Pouv, A. K., Rees, S. D., McGrath, A. P., Chang, G., & Hamdoun, A. (2021). Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares). Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, 248, 10. https://doi.org/10.1016/j.cbpc.2021.109101

Vacquier, V. D., & Hamdoun, A. (2021). New techniques for creating parthenogenetic larvae of the sea urchin Lytechinus pictus for gene expression studies. Developmental Dynamics. https://doi.org/10.1002/dvdy.377

Warner, J. F., Lord, J. W., Schreiter, S. A., Nesbit, K. T., Hamdoun, A., & Lyons, D. C. (2021). Chromosomal-level genome assembly of the painted sea urchin Lytechinus pictus: A genetically enabled model system for cell biology and embryonic development. Genome Biology and Evolution, 13(4). https://doi.org/10.1093/gbe/evab061

Schrankel, C. S., & Hamdoun, A. (2021). Early patterning of ABCB, ABCC, and ABCG transporters establishes unique territories of small molecule transport in embryonic mesoderm and endoderm. Developmental Biology, 472, 115–124. https://doi.org/10.1016/j.ydbio.2020.12.021

Fleming, T. J., Schrankel, C. S., Vyas, H., Rosenblatt, H. D., & Hamdoun, A. (2021). CRISPR/Cas9 mutagenesis reveals a role for ABCB1 in gut immune responses to Vibrio diazotrophicus in sea urchin larvae. Journal of Experimental Biology, 224(7). https://doi.org/10.1242/jeb.232272

Nicklisch, S. C. T., & Hamdoun, A. (2020). Disruption of small molecule transporter systems by Transporter-Interfering Chemicals (TICs). Febs Letters, 594(23), 4158–4185. https://doi.org/10.1002/1873-3468.14005

Nesbit, K. T., & Hamdoun, A. (2020). Embryo, larval, and juvenile staging of Lytechinus pictus from fertilization through sexual maturation. Developmental Dynamics. https://doi.org/10.1002/dvdy.223

Li, A. F., Espinoza, J., & Hamdoun, A. (2020). Inhibitory effects of neurotoxin beta-N-methylamino-L-alanine on fertilization and early development of the sea urchin Lytechinus pictus. Aquatic Toxicology, 221. https://doi.org/10.1016/j.aquatox.2020.105425

Gordon, W. E., Espinoza, J. A., Leerberg, D. M., Yelon, D., & Hamdoun, A. (2019). Xenobiotic transporter activity in zebrafish embryo ionocytes. Aquatic Toxicology, 212, 88–97. https://doi.org/10.1016/j.aquatox.2019.04.013

Shipp, L. E., Hill, R. Z., & Hamdoun, A. (2019). A teaching laboratory on the activation of xenobiotic transporters at fertilization of sea urchins. In K. R. Foltz & A. Hamdoun (Eds.), Echinoderms, Pt A (Vol. 150, pp. 429–447). Academic Press Ltd-Elsevier Science Ltd. https://doi.org/10.1016/bs.mcb.2018.11.013

Nesbit, K. T., Fleming, T., Batzel, G., Pouv, A., Rosenblatt, H. D., Pace, D. A., Hamdoun, A., & Lyons, D. C. (2019). The painted sea urchin, Lytechinus pictus, as a genetically-enabled developmental model. In K. R. Foltz & A. Hamdoun (Eds.), Echinoderms, Pt A (Vol. 150, pp. 105–123). Academic Press Ltd-Elsevier Science Ltd.

Campanale, J. P., Hamdoun, A., Wessel, G. M., Su, Y. H., & Oulhen, N. (2019). Methods to label, isolate, and image sea urchin small micromeres, the primordial germ cells (PGCs). In K. R. Foltz & A. Hamdoun (Eds.), Echinoderms, Pt A (Vol. 150, pp. 269-+). Academic Press Ltd-Elsevier Science Ltd.

Schrankel, C. S., Gokirmak, T., Lee, C. W., Chang, G., & Hamdoun, A. (2019). Generation, expression and utilization of single-domain antibodies for in vivo protein localization and manipulation in sea urchin embryos. In A. Hamdoun & K. R. Foltz (Eds.), Echinoderms, Pt B (Vol. 151, pp. 353–376). Academic Press Ltd-Elsevier Science Ltd.

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Barron, M. E., Thies, A. B., Espinoza, J. A., Barott, K. L., Hamdoun, A., & Tresguerres, M. (2018). A vesicular Na+/Ca2+ exchanger in coral calcifying cells. PLOS ONE, 13(10). https://doi.org/10.1371/journal.pone.0205367

Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce, N. T., Olson, J., Hensler, M. E., Choi, H., Campanale, J., Hamdoun, A., Nizet, V., Gerwick, W. H., Gaasterland, T., & Gerwick, L. (2018). Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. Journal of Natural Products, 81(3), 506–514. https://doi.org/10.1021/acs.jnatprod.7b00734

Nicklisch, S. C. T., Bonito, L. T., Sandin, S., & Hamdoun, A. (2017). Mercury levels of yellowfin tuna (Thunnus albacares) are associated with capture location. Environmental Pollution, 229, 87–93. https://doi.org/10.1016/j.envpol.2017.05.070

Nicklisch, S. C. T., Bonito, L. T., Sandin, S., & Hamdoun, A. (2017). Geographic differences in persistent organic pollutant levels of yellowfin tuna. Environ Health Perspect, 125(6), 067014. https://doi.org/10.1289/ehp518

Gokirmak, T., Campanale, J. P., Reitzel, A. M., Shipp, L. E., Moy, G. W., & Hamdoun, A. (2016). Functional diversification of sea urchin ABCC1 (MRP1) by alternative splicing. American Journal of Physiology-Cell Physiology, 310(11), C911–C920. https://doi.org/10.1152/ajpcell.00029.2016

Nicklisch, S. C. T., Rees, S. D., McGrath, A. P., Gökirmak, T., Bonito, L. T., Vermeer, L. M., Cregger, C., Loewen, G., Sandin, S., Chang, G., & Hamdoun, A. (2016). Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Science Advances, 2(4). https://doi.org/10.1126/sciadv.1600001

Bonito, L. T., Hamdoun, A., & Sandin, S. A. (2016). Evaluation of the global impacts of mitigation on persistent, bioaccumulative and toxic pollutants in marine fish. PeerJ, 4. https://doi.org/10.7717/peerj.1573

Shipp, L. E., Hill, R. Z., Moy, G. W., Gokirmak, T., & Hamdoun, A. (2015). ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos. Development, 142(20), 3537–3548. https://doi.org/10.1242/dev.126144

Gokirmak, T., Shipp, L. E., Campanale, J. P., Nicklisch, S. C. T., & Hamdoun, A. (2014). Transport in technicolor: Mapping ATP-binding cassette transporters in sea urchin embryos. Molecular Reproduction and Development, 81(9), 778–793. https://doi.org/10.1002/mrd.22357

Swartz, S. Z., Reich, A. M., Oulhen, N., Raz, T., Milos, P. M., Campanale, J. P., Hamdoun, A., & Wessel, G. M. (2014). Deadenylase depletion protects inherited mRNAs in primordial germ cells. Development, 141(16), 3134–3142. https://doi.org/10.1242/dev.110395

Campanale, J. P., Gokirmak, T., Espinoza, J. A., Oulhen, N., Wessel, G. M., & Hamdoun, A. (2014). Migration of sea urchin primordial germ cells. Developmental Dynamics, 243(7), 917–927. https://doi.org/10.1002/dvdy.24133

Cole, B. J., Hamdoun, A., & Epel, D. (2013). Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos. Journal of Experimental Biology, 216(20), 3896–3905. https://doi.org/10.1242/jeb.090522

Gokirmak, T., Campanale, J. P., Shipp, L. E., Moy, G. W., Tao, H. C., & Hamdoun, A. (2012). Localization and Substrate Selectivity of Sea Urchin Multidrug (MDR) Efflux Transporters. Journal of Biological Chemistry, 287(52), 43876–43883. https://doi.org/10.1074/jbc.M112.424879

Whalen, K., Reitzel, A. M., & Hamdoun, A. (2012). Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli. Molecular Biology of the Cell, 23(18), 3663–3672. https://doi.org/10.1091/mbc.E12-06-0438

Shipp, L. E., & Hamdoun, A. (2012). ATP-binding cassette (ABC) transporter expression and localization in sea urchin development. Developmental Dynamics, 241(6), 1111–1124. https://doi.org/10.1002/dvdy.23786

Campanale, J. P., & Hamdoun, A. (2012). Programmed reduction of ABC transporter activity in sea urchin germline progenitors. Development, 139(4), 783–792. https://doi.org/10.1242/dev.076752

Patel, S., Ramakrishnan, L., Rahman, T., Hamdoun, A., Marchant, J. S., Taylor, C. W., & Brailoiu, E. (2011). The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: Role for the two-pore channels. Cell Calcium, 50(2), 157–167. https://doi.org/10.1016/j.ceca.2011.03.011

Bosnjak, I., Uhlinger, K. R., Heim, W., Smital, T., Franekic-Colic, J., Coale, K., Epel, D., & Hamdoun, A. (2009). Multidrug Efflux Transporters Limit Accumulation of Inorganic, but Not Organic, Mercury in Sea Urchin Embryos. Environmental Science & Technology, 43(21), 8374–8380. https://doi.org/10.1021/es901677r

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Epel, D., Luckenbach, T., Stevenson, C. N., Macmanus-Spencer, L. A., Hamdoun, A., & Smital, T. (2008). Efflux transporters: Newly appreciated roles in protection against pollutants. Environmental Science & Technology, 42(11), 3914–3920. https://doi.org/10.1021/es087187v

Hamdoun, A., & Epel, D. (2007). Embryo stability and vulnerability in an always changing world. Proceedings of the National Academy of Sciences of the United States of America, 104(6), 1745–1750. https://doi.org/10.1073/pnas.0610108104

Roepke, T. A., Hamdoun, A. M., & Cherr, G. N. (2006). Increase in multidrug transport activity is associated with oocyte maturation in sea stars. Development Growth & Differentiation, 48(9), 559–573. https://doi.org/10.1111/j.1440-169x.2006.00893.x

Goldstone, J. V., Hamdoun, A., Cole, B. J., Howard-Ashby, M., Nebert, D. W., Scally, M., Dean, M., Epel, D., Hahn, M. E., & Stegeman, J. J. (2006). The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology, 300(1), 366–384. https://doi.org/10.1016/j.ydbio.2006.08.066

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Epel, D., Cole, B., Hamdoun, A., & Thurber, R. V. (2006). The sea urchin embryo as a model for studying efflux transporters: Roles and energy cost. Marine Environmental Research, 62, S1–S4. https://doi.org/10.1016/j.marenvres.2006.04.062