Publications

Barone, V., Tagua, A., Román, J. Á. A.-S., Hamdoun, A., Garrido-García, J., Lyons, D. C., & Escudero, L. M. (2024). Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium. Development, 151(20), dev202362. https://doi.org/10.1242/dev.202362
Vacquier, V. D., & Hamdoun, A. (2024). Cold storage and cryopreservation methods for spermatozoa of the sea urchins Lytechinus pictus and Strongylocentrotus purpuratus . Developmental Dynamics, dvdy.691. https://doi.org/10.1002/dvdy.691
Tjeerdema, E., Lee, Y., Metry, R., & Hamdoun, A. (2023). Semi‐automated, high‐content imaging of drug transporter knockout sea urchin ( Lytechinus pictus ) embryos. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, jez.b.23231. https://doi.org/10.1002/jez.b.23231
Michel, M. E., Wen, C. C., Yee, S. W., Giacomini, K. M., Hamdoun, A., & Nicklisch, S. C. T. (2023). TICBase : Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters. Clinical Pharmacology & Therapeutics, cpt.3036. https://doi.org/10.1002/cpt.3036
Lee, Y., Tjeerdema, E., Kling, S., Chang, N., & Hamdoun, A. (2023). Solute carrier (SLC) expression reveals skeletogenic cell diversity. Developmental Biology, 503, 68–82. https://doi.org/10.1016/j.ydbio.2023.08.004
Vyas, H., Schrankel, C. S., Espinoza, J. A., Mitchell, K. L., Nesbit, K. T., Jackson, E., Chang, N., Lee, Y., Warner, J., Reitzel, A., Lyons, D. C., & Hamdoun, A. (2022). Generation of a homozygous mutant drug transporter (ABCB1) knockout line in the sea urchin Lytechinus pictus. Development, 149(11), 7. https://doi.org/10.1242/dev.200644
Nicklisch, S. C. T., Pouv, A. K., Rees, S. D., McGrath, A. P., Chang, G., & Hamdoun, A. (2021). Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares). Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, 248, 10. https://doi.org/10.1016/j.cbpc.2021.109101
Vacquier, V. D., & Hamdoun, A. (2021). New techniques for creating parthenogenetic larvae of the sea urchin Lytechinus pictus for gene expression studies. Developmental Dynamics. https://doi.org/10.1002/dvdy.377
Warner, J. F., Lord, J. W., Schreiter, S. A., Nesbit, K. T., Hamdoun, A., & Lyons, D. C. (2021). Chromosomal-level genome assembly of the painted sea urchin Lytechinus pictus: A genetically enabled model system for cell biology and embryonic development. Genome Biology and Evolution, 13(4). https://doi.org/10.1093/gbe/evab061
Schrankel, C. S., & Hamdoun, A. (2021). Early patterning of ABCB, ABCC, and ABCG transporters establishes unique territories of small molecule transport in embryonic mesoderm and endoderm. Developmental Biology, 472, 115–124. https://doi.org/10.1016/j.ydbio.2020.12.021
Fleming, T. J., Schrankel, C. S., Vyas, H., Rosenblatt, H. D., & Hamdoun, A. (2021). CRISPR/Cas9 mutagenesis reveals a role for ABCB1 in gut immune responses to Vibrio diazotrophicus in sea urchin larvae. Journal of Experimental Biology, 224(7). https://doi.org/10.1242/jeb.232272
Nicklisch, S. C. T., & Hamdoun, A. (2020). Disruption of small molecule transporter systems by Transporter-Interfering Chemicals (TICs). Febs Letters, 594(23), 4158–4185. https://doi.org/10.1002/1873-3468.14005
Nesbit, K. T., & Hamdoun, A. (2020). Embryo, larval, and juvenile staging of Lytechinus pictus from fertilization through sexual maturation. Developmental Dynamics. https://doi.org/10.1002/dvdy.223
Li, A. F., Espinoza, J., & Hamdoun, A. (2020). Inhibitory effects of neurotoxin beta-N-methylamino-L-alanine on fertilization and early development of the sea urchin Lytechinus pictus. Aquatic Toxicology, 221. https://doi.org/10.1016/j.aquatox.2020.105425
Gordon, W. E., Espinoza, J. A., Leerberg, D. M., Yelon, D., & Hamdoun, A. (2019). Xenobiotic transporter activity in zebrafish embryo ionocytes. Aquatic Toxicology, 212, 88–97. https://doi.org/10.1016/j.aquatox.2019.04.013
Nesbit, K. T., Fleming, T., Batzel, G., Pouv, A., Rosenblatt, H. D., Pace, D. A., Hamdoun, A., & Lyons, D. C. (2019). The painted sea urchin, Lytechinus pictus, as a genetically-enabled developmental model. In K. R. Foltz & A. Hamdoun (Eds.), Echinoderms, Pt A (Vol. 150, pp. 105–123). Academic Press Ltd-Elsevier Science Ltd.
Shipp, L. E., Hill, R. Z., & Hamdoun, A. (2019). A teaching laboratory on the activation of xenobiotic transporters at fertilization of sea urchins. In K. R. Foltz & A. Hamdoun (Eds.), Echinoderms, Pt A (Vol. 150, pp. 429–447). Academic Press Ltd-Elsevier Science Ltd.
Campanale, J. P., Hamdoun, A., Wessel, G. M., Su, Y. H., & Oulhen, N. (2019). Methods to label, isolate, and image sea urchin small micromeres, the primordial germ cells (PGCs). In K. R. Foltz & A. Hamdoun (Eds.), Echinoderms, Pt A (Vol. 150, pp. 269-+). Academic Press Ltd-Elsevier Science Ltd.
Schrankel, C. S., Gokirmak, T., Lee, C. W., Chang, G., & Hamdoun, A. (2019). Generation, expression and utilization of single-domain antibodies for in vivo protein localization and manipulation in sea urchin embryos. In A. Hamdoun & K. R. Foltz (Eds.), Echinoderms, Pt B (Vol. 151, pp. 353–376). Academic Press Ltd-Elsevier Science Ltd.
Foltz, K. R., & Hamdoun, A. (2019). Echinoderms, Part A. In K. R. Foltz & A. Hamdoun (Eds.), Echinoderms, Pt A (Vol. 150, p. XIX–XX). Academic Press Ltd-Elsevier Science Ltd.
Barron, M. E., Thies, A. B., Espinoza, J. A., Barott, K. L., Hamdoun, A., & Tresguerres, M. (2018). A vesicular Na+/Ca2+ exchanger in coral calcifying cells. PLOS ONE, 13(10). https://doi.org/10.1371/journal.pone.0205367
Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce, N. T., Olson, J., Hensler, M. E., Choi, H., Campanale, J., Hamdoun, A., Nizet, V., Gerwick, W. H., Gaasterland, T., & Gerwick, L. (2018). Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. Journal of Natural Products, 81(3), 506–514. https://doi.org/10.1021/acs.jnatprod.7b00734
Nicklisch, S. C. T., Bonito, L. T., Sandin, S., & Hamdoun, A. (2017). Mercury levels of yellowfin tuna (Thunnus albacares) are associated with capture location. Environmental Pollution, 229, 87–93. https://doi.org/10.1016/j.envpol.2017.05.070
Nicklisch, S. C. T., Bonito, L. T., Sandin, S., & Hamdoun, A. (2017). Geographic differences in persistent organic pollutant levels of yellowfin tuna. Environ Health Perspect, 125(6), 067014. https://doi.org/10.1289/ehp518
Gokirmak, T., Campanale, J. P., Reitzel, A. M., Shipp, L. E., Moy, G. W., & Hamdoun, A. (2016). Functional diversification of sea urchin ABCC1 (MRP1) by alternative splicing. American Journal of Physiology-Cell Physiology, 310(11), C911–C920. https://doi.org/10.1152/ajpcell.00029.2016
Nicklisch, S. C. T., Rees, S. D., McGrath, A. P., Gökirmak, T., Bonito, L. T., Vermeer, L. M., Cregger, C., Loewen, G., Sandin, S., Chang, G., & Hamdoun, A. (2016). Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Science Advances, 2(4). https://doi.org/10.1126/sciadv.1600001
Bonito, L. T., Hamdoun, A., & Sandin, S. A. (2016). Evaluation of the global impacts of mitigation on persistent, bioaccumulative and toxic pollutants in marine fish. PeerJ, 4. https://doi.org/10.7717/peerj.1573
Shipp, L. E., Hill, R. Z., Moy, G. W., Gokirmak, T., & Hamdoun, A. (2015). ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos. Development, 142(20), 3537–3548. https://doi.org/10.1242/dev.126144
Gokirmak, T., Shipp, L. E., Campanale, J. P., Nicklisch, S. C. T., & Hamdoun, A. (2014). Transport in technicolor: Mapping ATP-binding cassette transporters in sea urchin embryos. Molecular Reproduction and Development, 81(9), 778–793. https://doi.org/10.1002/mrd.22357
Swartz, S. Z., Reich, A. M., Oulhen, N., Raz, T., Milos, P. M., Campanale, J. P., Hamdoun, A., & Wessel, G. M. (2014). Deadenylase depletion protects inherited mRNAs in primordial germ cells. Development, 141(16), 3134–3142. https://doi.org/10.1242/dev.110395
Campanale, J. P., Gokirmak, T., Espinoza, J. A., Oulhen, N., Wessel, G. M., & Hamdoun, A. (2014). Migration of sea urchin primordial germ cells. Developmental Dynamics, 243(7), 917–927. https://doi.org/10.1002/dvdy.24133
Cole, B. J., Hamdoun, A., & Epel, D. (2013). Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos. Journal of Experimental Biology, 216(20), 3896–3905. https://doi.org/10.1242/jeb.090522
Gokirmak, T., Campanale, J. P., Shipp, L. E., Moy, G. W., Tao, H. C., & Hamdoun, A. (2012). Localization and Substrate Selectivity of Sea Urchin Multidrug (MDR) Efflux Transporters. Journal of Biological Chemistry, 287(52), 43876–43883. https://doi.org/10.1074/jbc.M112.424879
Whalen, K., Reitzel, A. M., & Hamdoun, A. (2012). Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli. Molecular Biology of the Cell, 23(18), 3663–3672. https://doi.org/10.1091/mbc.E12-06-0438
Shipp, L. E., & Hamdoun, A. (2012). ATP-binding cassette (ABC) transporter expression and localization in sea urchin development. Developmental Dynamics, 241(6), 1111–1124. https://doi.org/10.1002/dvdy.23786
Campanale, J. P., & Hamdoun, A. (2012). Programmed reduction of ABC transporter activity in sea urchin germline progenitors. Development, 139(4), 783–792. https://doi.org/10.1242/dev.076752
Patel, S., Ramakrishnan, L., Rahman, T., Hamdoun, A., Marchant, J. S., Taylor, C. W., & Brailoiu, E. (2011). The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: Role for the two-pore channels. Cell Calcium, 50(2), 157–167. https://doi.org/10.1016/j.ceca.2011.03.011
Bosnjak, I., Uhlinger, K. R., Heim, W., Smital, T., Franekic-Colic, J., Coale, K., Epel, D., & Hamdoun, A. (2009). Multidrug Efflux Transporters Limit Accumulation of Inorganic, but Not Organic, Mercury in Sea Urchin Embryos. Environmental Science & Technology, 43(21), 8374–8380. https://doi.org/10.1021/es901677r
Hamdoun, A. (2009). Reduced intracellular accumulation of calcein by overexpression of fluorescent protein fusions of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos. Mount Desert Island Biological Laboratory Bulletin, 48, 59–62.
Epel, D., Luckenbach, T., Stevenson, C. N., Macmanus-Spencer, L. A., Hamdoun, A., & Smital, T. (2008). Efflux transporters: Newly appreciated roles in protection against pollutants. Environmental Science & Technology, 42(11), 3914–3920. https://doi.org/10.1021/es087187v
Hamdoun, A., & Epel, D. (2007). Embryo stability and vulnerability in an always changing world. Proceedings of the National Academy of Sciences of the United States of America, 104(6), 1745–1750. https://doi.org/10.1073/pnas.0610108104
Roepke, T. A., Hamdoun, A. M., & Cherr, G. N. (2006). Increase in multidrug transport activity is associated with oocyte maturation in sea stars. Development Growth & Differentiation, 48(9), 559–573. https://doi.org/10.1111/j.1440-169x.2006.00893.x
Goldstone, J. V., Hamdoun, A., Cole, B. J., Howard-Ashby, M., Nebert, D. W., Scally, M., Dean, M., Epel, D., Hahn, M. E., & Stegeman, J. J. (2006). The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology, 300(1), 366–384. https://doi.org/10.1016/j.ydbio.2006.08.066
Sea Urchin Genome Sequencing Consortium. (2006). Research article - The genome of the sea urchin Strongylocentrotus purpuratus. Science, 314(5801), 941–952. https://doi.org/10.1126/science.1133609
Epel, D., Cole, B., Hamdoun, A., & Thurber, R. V. (2006). The sea urchin embryo as a model for studying efflux transporters: Roles and energy cost. Marine Environmental Research, 62, S1–S4. https://doi.org/10.1016/j.marenvres.2006.04.062
Hamdoun, A. M., Cherr, G. N., Roepke, T. A., & Epel, D. (2004). Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus). Developmental Biology, 276(2), 452–462. https://doi.org/10.1016/j.ydbio.2004.09.013
Smital, T., Luckenbach, T., Sauerborn, R., Hamdoun, A. M., Vega, R. L., & Epel, D. (2004). Emerging contaminants--pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms. Mutation Research, 552(1–2), 101–117. https://doi.org/10.1016/j.mrfmmm.2004.06.006
Hamdoun, A. M., Cheney, D. P., & Cherr, G. N. (2003). Phenotypic plasticity of HSP70 and HSP70 gene expression in the Pacific oyster (Crassostrea gigas): Implications for thermal limits and induction of thermal tolerance. Biological Bulletin, 205(2), 160–169. https://doi.org/10.2307/1543236
Hamdoun, A. M., Griffin, F. J., & Cherr, G. N. (2002). Tolerance to biodegraded crude oil in marine invertebrate embryos and larvae is associated with expression of a multixenobiotic resistance transporter. Aquatic Toxicology, 61(1–2), 127–140. https://doi.org/10.1016/s0166-445x(02)00050-4